Retinal Degeneration – Potsdam Meeting der ProRetina Stiftung 2020

15th PRO RETINA Research Colloquium on Retinal Degeneration

Update on innovative apporaches – an interdisciplinary dialogue

Friday, April 03, 2020

13:00 – 13:05 Welcome remarks Franz Badura (Amberg, Germany)

13:05 – 14:30 SESSION 1 Selected poster presentations Eight abstracts to be selected

14:30 – 15:00 Keynote lecture Krzysztof Palczewski (Irvine, USA) Systems pharmacology for acquired and inherited retinal diseases

15:00 – 15:45 Coffee break

15:45 – 17:25 SESSION 2 Precision medicine – innovative approaches

15:45 – 16:10 Rob W. J. Collin (Nijmegen, The Netherlands) Splicing modulation therapy for inherited retinal disease using antisense oligonucleotides

16:10 – 16:35 Mathew Pletcher (Basel, Switzerland) Precision medicine for rare diseases – challenges and opportunities. An industry perspective

16:35 – 17:00 Yasmina Cehajic-Kapetanovic (Oxford, UK) Gene therapy for RPGR-related RP – strategy and first results from a clinical trial

17:00 – 17:25 Hendrik Scholl (Basel, Switzerland) Pharmacotherapy for Stargardt disease

17:30 Dinner

19:00 – 20:00 EVENING LECTURE Peter Campochiaro (Baltimore, USA) Oxidative damage and cone dysfunction and degeneration in retinitis pigmentosa

20:00 – open Swingin’ poster session

Saturday, April 04, 2020

09:00 – 10:40 SESSION 3 Innovative model systems and technologies

09:00 – 09:25 Patricia Berber (Regensburg, Germany) An introduction to retinal organoids

09:25 – 09:50 Mike Karl (Dresden, Germany) Human retina organoid model for macular degeneration

09:50 – 10:15 Dwight Stambolian (Pennsylvania, USA) Using single cell RNA-seq to understand dysfunction in age-related macular degeneration

10:15 – 10:40 Elvir Becirovic (München, Germany) CRISPR/Cas9-mediated gene activation: A versatile approach for treatment of inherited retinal diseases

10:40 – 11:15 Coffee break

11:15 – 12:55 SESSION 4 Immunity and the retina

11:15 – 11:40 Mike Sapieha (Montreal, Canada) Innate immunity in retinal vascular remodeling

11:40 – 12:05 Martin Zinkernagel (Bern, Switzerland) Non-invasive imaging of immune cells in the retina

12:05 – 12:30 Anne Wolf (Köln, Germany) TSPO links reactive oxygen species with neurotoxic microglia

12:30 – 12:55 Torben Lykke Sørensen (Kopenhagen, Denmark) Systemic immune activation in AMD

12:55 – 13:00 Concluding remarks

13:00 Lunch and end of meeting